Basic Information

IDDRAMP20837
SequenceKRVKRFKKFFRKIKKGFRKIFKKTKIFIGGT
Length31
NamePb-CATH1 Python bivittatus antimicrobial peptides peptide derivative
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.28630199]Gram-negative bacteria:Escherichia coli (ATCC 25922)(MIC=2μg/ml);Pseudomonas aeruginosa (ATCC 27853)(MIC=3μg/ml);S. typhimurium (ATCC 14028)(MIC=1.5μg/ml);##Gram-positive bacteria:Staphylococcus aureus (ATCC 29213)(MIC>128μg/ml);B. cereus (ATCC 10876)(MIC=46μg/ml)
Hemolytic Activity[Ref.28630199] 0% hemolysis at 4μg/ml against human red blood cell; 1.4 ± 0.4% hemolysis at 8μg/ml against human red blood cell; 5.1 ± 0.5% hemolysis at 16μg/ml against human red blood cell;7.3 ± 0.6% hemolysis at 32μg/ml against human red blood cell; 12.2 ± 0.7% hemolysis at 64μg/ml against human red blood cell
Cytotoxicity[Ref.28630199] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID28630199

Physicochemical Properties

Residues31
SequenceKRVKRFKKFFRKIKKGFRKIFKKTKIFIGGT
Molecular Weight3860.819
Grand Average of Hydropathy-0.79
Isoelectric Point12
Charge at pH 7.414.53
Secondary StructureHelix: 0.355, Turn: 0.097, Sheet: 0.000
Instability Index7.632
Aromaticity0.194

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