Basic Information
| ID | DRAMP20970 |
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| Sequence | VNFKLLSHSLLVTLASHL |
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| Length | 18 |
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| Name | P3 (bovine cathelicidin, cattle, ruminant, mammals, animals) |
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| Source | Bos taurus (Bovine) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
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| Pathogen | [Ref.25753638] Gram-positive bacteria : Staphylococcus aureus ATCC29213 (MIC=25 μg/ml), Clinical Staphylococcus aureus (MIC=12.5 μg/ml);##Gram-negative bacteria : Escherichia coli ATCC25922 (MIC=12.5 μg/ml), Clinical Escherichia coli (MIC=12.5 μg/ml), Pseudomonas aeruginosa clinical strain (MIC=25 μg/ml);##Fungi : Candida albicans Clinical strain (MIC=25 μg/ml), Candida albicans ATCC 90029 (MIC=50 μg/ml) |
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| Hemolytic Activity | [Ref.25753638] 3% hemolysis at 50 μg/ml , 5% hemolysis at 100 μg/ml , 7% hemolysis at 200 μg/ml , 7.5% hemolysis at 300 μg/ml , 8% hemolysis at 400 μg/ml against human red blood cells |
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| Cytotoxicity | [Ref.25753638] The cell viability of HaCaT cell lines is 93% and 94% at peptide concentrations of 200 and 400 μg/ml. In kumning mice, the LD50 of P3 is 160 mg/kg for i.p. injection, while the LD50 of PMB(served as a control) is 50 mg/kg. No mortality w |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
P01966 |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 25753638 |
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