| ID | DRAMP20984 |
|---|---|
| Sequence | KFWKLLKKALRLWAKVL |
| Length | 17 |
| Name | CPF-3 (Derived from CPF-C1) |
| Source | Synthetic construct |
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
| Pathogen | [Ref.28371431]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=16 μg/ml), Staphylococcuss aureus 725 (MIC=8 μg/ml), Staphylococcuss aureus 794 (MIC=8 μg/ml), Staphylococcuss aureus 936 (MIC=16 μg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=8 μg/ml), Escherichia coli 780 (MIC=8 μg/ml), Escherichia coli 804 (MIC=8 μg/ml), Escherichia coli 850 (MIC=16 μg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=16 μg/ml), Pseudomonas aeruginosa 2760 (MIC=16 μg/ml), Pseudomonas aeruginosa 9132 (MIC=16 μg/ml), Acinetobacter baumannii ATCC 19606 (MIC=8 μg/ml), Acinetobacter baumannii 1980 (MIC=16 μg/ml), Acinetobacter baumannii 2982 (MIC=16 μg/ml), Acinetobacter baumannii 4956 (MIC=16 μg/ml) |
| Hemolytic Activity | [Ref.28371431] 0% hemolysis at 256 μg/ml , 5% hemolysis at 512 μg/ml against human red blood cells |
| Cytotoxicity | [Ref.28371431] No cytotoxicity information found |
| N-terminal Modification | Free |
| C-terminal Modification | Amidation |
| Linear/Cyclic/Branched | Linear |
| Uniprot | |
| PDB | |
| 3D View | |
| PDB Download | Download PDB Predicted by Alphafold2 |
| PubMed ID | 28371431 |
Physicochemical Properties
| Residues | 17 |
|---|---|
| Sequence | KFWKLLKKALRLWAKVL |
| Molecular Weight | 2141.731 |
| Grand Average of Hydropathy | 0.224 |
| Isoelectric Point | 11.388 |
| Charge at pH 7.4 | 5.545 |
| Secondary Structure | Helix: 0.529, Turn: 0.000, Sheet: 0.412 |
| Instability Index | 10.847 |
| Aromaticity | 0.176 |
