Basic Information
| ID | DRAMP21110 |
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| Sequence | LRRLLRWLRRLLRR |
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| Length | 14 |
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| Name | SLZP (De novo synthesis) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
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| Pathogen | [Ref.25069749] Gram-positive bacteria : Staphylococcus aureus (ATCC 25923)(MIC=1.56 μg/ml), Bacillus cereus(MIC=3.15 μg/ml);##Gram-negative bacteria : E. coli (ATCC 9637)(MIC=25 μg/ml), Pseudomonas aeruginosa (ATCC BAA-427)(MIC=25 μg/ml), Klebsiella pneumoniae (ATCC 27736)(MIC=3.15 μg/ml);##Fungi : Sporothrix schenckii(MIC=3.15 μg/ml), Trichophyton mentagrophytes(MIC=6.25 μg/ml), Aspergillus fumigatus(MIC=6.25 μg/ml), Candida parapsilosis (ATCC 22019)(MIC=6.25 μg/ml) |
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| Hemolytic Activity | [Ref.25069749] 15% hemolysis at 10 μg/ml , 25% hemolysis at 20 μg/ml , 30% hemolysis at 30 μg/ml , 40% hemolysis at 40 μg/ml , 50% hemolysis at 50 μg/ml , 55% hemolysis at 60 μg/ml , 70% hemolysis at 70 μg/ml , 80% hemolysis at 80μg/ml against human red blood cells |
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| Cytotoxicity | [Ref.25069749] The cell viability of murine fibroblast cells (3T3) is 85.9%, 77.5%, 73.7%, 50.0%, 23.7% and 0% at peptide concentrations of 1.5, 3, 4.5, 6 and 9 μM. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 25069749 |
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