Basic Information
| ID | DRAMP21147 |
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| Sequence | KRIVQRIKKWLR |
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| Length | 12 |
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| Name | KR-12-a2 (Derived from KR-12) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.24105706] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=8 μM), Staphylococcus epidermidis (KCTC 1917)(MIC=1 μM), Staphylococcus aureus (KCTC 1621)(MIC=2 μM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=2 μM), Pseudomonas aeruginosa (KCTC 1637)(MIC=8 μM), Salmonella typhimurium (KCTC 1926)(MIC=1 μM) |
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| Hemolytic Activity | [Ref.24105706] HC50>800 μM against human red blood cells |
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| Cytotoxicity | [Ref.24105706] The cell viability of RAW264.7 macrophage cells is 111.9%, 103.4%, 102.2%, 102.2%, 100%, 101.2%, 112.5% and 95.0% at peptide concentrations of 0.78, 1.56, 3.12, 6.25, 12.5, 25, 50 and 100 μM. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 24105706 |
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