Basic Information

IDDRAMP21175
SequenceGKLSSLWKKLKKIIAK
Length16
NameHYL-22 (Derived from HYL)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=26 μM), Staphylococcus epidermidis(MIC=2.5 μM);##Gram-negative bacteria : Escherichia coli(MIC=20 μM), Pseudomonas aeruginosa 5482(MIC=6.8 μM);##Fungi : Candida albicans(MIC=34 μM)
Hemolytic Activity[Ref.26998557] LC50>400 μM against human red blood cells
Cytotoxicity[Ref.26998557] No cytotoxicity information found.
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID26998557

Physicochemical Properties

Residues16
SequenceGKLSSLWKKLKKIIAK
Molecular Weight1841.331
Grand Average of Hydropathy-0.256
Isoelectric Point10.699
Charge at pH 7.45.542
Secondary StructureHelix: 0.375, Turn: 0.188, Sheet: 0.250
Instability Index9.681
Aromaticity0.062

Similar Structure Search

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