Basic Information
| ID | DRAMP21246 |
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| Sequence | KKWRWWLKALAKK |
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| Length | 13 |
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| Name | pEM-2 (Derived from the venom of the snake Bothrops asper) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.27591703] Gram-positive bacteria : Staphylococcus aureus isolates(MIC=5.3 ± 2.3 mg/L, MBC=6.7 ± 2.3 mg/L), Enterococcus faecalis isolates(MIC=6.7 ± 2.3 mg/L, MBC=8.0 ± 0.0 mg/L);##Gram-negative bacteria : Pseudomonas aeruginosa isolates(MIC=4.0 ± 3.5 mg/L, MBC=4.0 ± 3.5 mg/L), Acinetobacter baumannii isolates(MIC=4.0 ± 0.0 mg/L, MBC=5.3 ± 2.3 mg/L) |
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| Hemolytic Activity | [Ref.27591703] 0% hemolysis at 2 μg/ml , 5% hemolysis at 4 μg/ml , 15% hemolysis at 8 μg/ml , 55% hemolysis at 16 μg/ml , 87% hemolysis at 32 μg/ml , 92% hemolysis at 64 μg/ml against human red blood cells; 0% hemolysis at 16 μg/ml , 2.5% hemolysis at 32 μg/ml , 10% hemolysis at 64 μg/ml against sheep red blood cells |
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| Cytotoxicity | [Ref.27591703] The cell viability of HEK293 cells induced by PV is 99.1%, 99.1%, 98.3%, 94.8%, 93.9%, 87.5% and 84.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 μg/mL within 24h. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 27591703 |
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