Basic Information
| ID | DRAMP21261 |
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| Sequence | LLKAAAKAAAKLL |
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| Length | 13 |
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| Name | KL4A6 (De novo synthesis) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.26385363] Gram-positive bacteria : Staphylococcus aureus ATCC 29213(MIC>128 μM), Staphylococcus epidermidis ATCC 12228(MIC=128 μM), Streptococcus faecalis ATCC 29212(MIC=16 μM), Bacillus subtilis CMCC 63501(MIC=32 μM);##Gram-negative bacteria : Escherichia coli ATCC25922(MIC=2 μM), Escherichia coli K88(MIC=32 μM), Escherichia coli CVCC 1515(MIC=32 μM), Escherichia coli UB1005(MIC=32 μM), Bacterium pyocyaneum ATCC 27853(MIC>128 μM), Salmonella typhimurium ATCC 14028(MIC=128 μM), Salmonella pullorum C79–13(MIC>128 μM) |
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| Hemolytic Activity | [Ref.26385363] MHC5>256 μM against human red blood cells |
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| Cytotoxicity | [Ref.26385363] The cell viability of HEK293 cells induced by KL4A6 is 107.8%, 108.3%, 104.4%, 104.7%, 105.6%, 100%, 94.4% and 96.7% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 μM. The cell viability of HEK293 cells induced by control Meli |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 26385363 |
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