ABPDB

Basic Information

ID	DRAMP29112
Sequence	LNLKALAAVAKKIL
Length	14
Name	Mastoparan-C [L7A]
Source	Synthetic construct
Activity	Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-
Pathogen	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=16 µM); Bacillus subtilis ATCC 23857(MIC=8 µM); ##Gram-negative bacteria:Escherichia coli ATCC 25922(4.5 mM KCl and 0.004 mM FeCl3,MIC=8 µM); Pseudomonas aeruginosa ATCC 9027(4.5 mM KCl,MIC=16 µM); Klebsiella pneumoniae ATCC 700603(MIC=16 µM); Escherichia coli ATCC 25922(150mM NaCl,MIC=32 µM); Escherichia coli ATCC 25922(1mM MgCl2,MIC=16 µM); Pseudomonas aeruginosa ATCC 9027(150mM NaCl,MIC=32 µM); Pseudomonas aeruginosa ATCC 9027(1mM MgCl2,MIC=64 µM); Pseudomonas aeruginosa ATCC 9027(0.004mM FeCl3,MIC=8 µM);Escherichia coli(Rifampin-resistant strain,MIC=8 µM).
Hemolytic Activity	[Ref.33285267]8% hemolysis against mouse erythrocytes at 256 µM.
Cytotoxicity	[Ref.33285267]45% Killing against Human embryonic kidney HEK293T cells at 128 µM; Human embryonic kidney HEK293T cells(IC50>128 µM).
N-terminal Modification	Free
C-terminal Modification	Amidation
Linear/Cyclic/Branched	Linear
Uniprot	P01516
PDB
3D View
PDB Download	Download PDB Predicted by Alphafold2
PubMed ID	33285267

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