Basic Information
| ID | DRAMP21368 |
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| Sequence | KLGALWNVAKSKF |
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| Length | 13 |
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| Name | [Lys]1[Lys]12-VmCT1-NH2 (Derived from VmCT1) |
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| Source | synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
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| Pathogen | [Ref.31181304] Gram-positive bacteria: Micrococcus luteus A270 (MIC=12.5 μmol/L), Bacillus megaterium ATCC 10778 (MIC=6.3 μmol/L);##Gram-negative bacteria: Enterobacter cloacae β-12 (MIC=25μmol/L);##Fungi: Candida albicans MDM8 (MIC=6.3 μmol/L), Candida tropicalis IOC 4560 (MIC=3.1 μmol/L) |
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| Hemolytic Activity | [Ref.31181304] 0% hemolysis at 100 μmol/L against human red blood cells |
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| Cytotoxicity | [Ref.31181304] The cell viability of MCF-7 cells induced by [Lys1][Lys12]-VmCT1-NH2 is 105%, 110%, 95%, 100%, 110%, 120%, 120% and 120% at peptide concentrations of 0.8, 1.6, 3.1, 12.5, 25, 50 and 100 μM. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 31181304 |
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