Basic Information
| ID | DRAMP29054 |
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| Sequence | SLRGCC |
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| Length | 6 |
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| Name | RcAlb-PepII (designed in silico using as template the amino acid sequence of Rc-2S-Alb) |
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| Source | Synthetic construct (Rc-2S-Alb comes from Ricinus communis (Castor bean)) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
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| Pathogen | [Ref.31678367] Gram-negative bacteria: E. coli (MIC50 = 31 μM, MIC90 = 29 μM, MBC > 250 μM), K. pneumoniae(MIC50 = 11 μM, MIC90 = 21 μM, MBC = 42 μM)##Gram-positive bacteria: S. aureus (MIC50 = 79 μM, MIC90 > 250 μM, MBC > 250 μM)##Yeast: C. albicans (MIC50 = 129 μM, MIC90 > 250 μM, MFC > 250 μM), C. parapsilosis (MIC50 = 9 μM, MIC90 = 17 μM, MFC = 25 μM), C. tropicalis (MIC50 = 29 μM, MIC90 = 28 μM, MFC = 67 μM) |
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| Hemolytic Activity | [Ref.31678367] RcAlb-PepII was not harmful to human erythrocytes, even at a concentration 10 times higher than the MBC and MFC for K. pneumoniae and C. parapsilosis, respectively. |
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| Cytotoxicity | [Ref.31678367] At 420 μM concentration (10 and 16.8 times higher than the MBC and MFC for K. pneumoniae and C. parapsilosis, respectively) RcAlb-PepII reduced only in 21.5% the Vero cell viability |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 31678367 |
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