Basic Information
| ID | DRAMP29105 |
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| Sequence | CLNLKALLAVAKKILC |
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| Length | 16 |
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| Name | c Mastoparan-C(cMP-C) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Anti-cancer,Antifungal |
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| Pathogen | [Ref.29904274]Gram-positive bacteria:Staphylococcus aureus NCTC 10788(MIC=32 µM); Staphylococcus aureus NCTC 10788(MBC=64 µM); Staphylococcus aureus ATCC 12493(MRSA,MIC=128 µM); Staphylococcus aureus ATCC 12493(MRSA,MBC=128 µM); Enterococcus faecalis NCTC 12697(MIC=128 µM); Enterococcus faecalis NCTC 12697(MBC=128 µM);##Gram-negative bacteria:Escherichia coli NCTC 10418(MIC=32 µM); Escherichia coli NCTC 10418(MBC=128 µM); Pseudomonas aeruginosa ATCC 27853(MIC=32 µM); Pseudomonas aeruginosa ATCC 27853(MBC>512 µM);##Fungi:Candida albicans NCTC 1467(MIC=32 µM); Candida albicans NCTC 1467(MBC=128 µM);##Cancer:Human squamous lung carcinoma NCI-H157(IC50=7.02 µM);Human breast adenocarcinoma MDA-MB-435S(IC50=13.87 µM);Human prostate adenocarcinoma PC-3(IC50=13.87 µM);Human glioblastoma U251-MG(IC50=8.56 µM); Human breast adenocarcinoma MCF-7(IC50=13.66 µM). |
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| Hemolytic Activity | [Ref.29904274]50% hemolysis against horse erythrocytes at 9.19 µM. |
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| Cytotoxicity | [Ref.29904274]Cytotoxicity:Human microvascular endothelial cells HMEC-1(IC50=39.53 µM). |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Cyclic |
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| Uniprot |
P01516 |
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| PDB |
|
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 29904274 |
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