Basic Information

IDDRAMP01248
SequenceFLIGMTHGLICLISRKC
Length17
NameDybowskin-1 (Frogs, amphibians, animals)
SourceRana dybowskii (Korea brown frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+
Pathogen[Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=12.5 µg/ml), Staphylococcus aureus KCTC3881 (MIC=25 µg/ml), Bacillus subtilis ATCC6633 (MIC=50 µg/ml), Staphylococcus epidermidis ATCC 12228 (MIC=60 µg/ml).
Hemolytic Activity[Ref:17698251] It has 0.99% hemolytic activity at 100 μg/ml against huamn red blood cells
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys11 and Cys17)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID17698251

Physicochemical Properties

Residues17
SequenceFLIGMTHGLICLISRKC
Molecular Weight1905.398
Grand Average of Hydropathy1.218
Isoelectric Point8.957
Charge at pH 7.41.543
Secondary StructureHelix: 0.412, Turn: 0.176, Sheet: 0.235
Instability Index24.276
Aromaticity0.059

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.