Basic Information

IDDRAMP01305
SequenceFLSLIPHAINAVSAIAKHFG
Length20
NamePhylloseptin-7 (PS-7; Frogs, amphibians, animals)
SourcePhyllomedusa hypochondrialis (Orange-legged leaf frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.16963159]Gram-negative bacteria: Escherichia coli (MIC=6 µM), Pseudomonas aeruginosa (MIC=6 µM);##Gram-positive bacterium: Staphylococcus aureus (MIC=6 µM)
Hemolytic Activity[Ref:16963159]Non-hemolytic activity at 6 μM against human erythrocytes
Cytotoxicity[Ref.16713656]No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot P84572, Q0VZ42
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16963159, 16713656

Physicochemical Properties

Residues20
SequenceFLSLIPHAINAVSAIAKHFG
Molecular Weight2106.468
Grand Average of Hydropathy1.035
Isoelectric Point8.764
Charge at pH 7.40.628
Secondary StructureHelix: 0.400, Turn: 0.250, Sheet: 0.300
Instability Index2.875
Aromaticity0.1

Similar Structure Search

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