Basic Information

IDDRAMP01414
SequenceGIFSTVFKAGKGIVCGLTGLC
Length21
NameNigrocin-2ISa (Frogs, amphibians, animals)
SourceOdorrana ishikawae (Ishikawa's frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacterium: Escherichia coli (MIC=25 µM);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 µM), Staphylococcus aureus (MRSA) (MIC=12.5 µM), Bacillus subtilis (MIC=12.5 µM).##Yeast: Candida albicans (MIC=50 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity[Ref.21193000]No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys15 and Cys21)
Linear/Cyclic/BranchedCyclic
Uniprot F1T156
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID21193000

Physicochemical Properties

Residues21
SequenceGIFSTVFKAGKGIVCGLTGLC
Molecular Weight2071.505
Grand Average of Hydropathy1.21
Isoelectric Point8.904
Charge at pH 7.41.503
Secondary StructureHelix: 0.381, Turn: 0.286, Sheet: 0.143
Instability Index-21.89
Aromaticity0.095

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.