Basic Information

IDDRAMP01432
SequenceGILGNIVGMGKKIVCGLSGLC
Length21
NameNigrocin-1-OW2 (Frogs, amphibians, animals)
SourceOdorrana andersonii (Asian frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.2 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.4 µg/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.2 µg/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3.1 µg/ml).
Hemolytic Activity[Ref:22029824] Not found in the literature
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys15 and Cys21)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22029824

Physicochemical Properties

Residues21
SequenceGILGNIVGMGKKIVCGLSGLC
Molecular Weight2032.537
Grand Average of Hydropathy1.224
Isoelectric Point8.904
Charge at pH 7.41.503
Secondary StructureHelix: 0.381, Turn: 0.381, Sheet: 0.190
Instability Index11.319
Aromaticity0

Similar Structure Search

Candidates based on structure

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