Basic Information

IDDRAMP01444
SequenceGLLDSIKGMAISAGKGALQNLLKVASCKLDKTC
Length33
NameNigrocin-1 (Frogs, amphibians, animals)
SourcePelophylax nigromaculatus (Black-spotted frog) (Rana nigromaculata) (frog skin active peptide)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.11682065]Gram-positive bacterium: Micrococcus luteus(MIC=2.5μg/ml);##Gram-negative bacteria: Shigella dysenteriae(MIC=10μg/ml), Klebsiella pneumoniae(MIC=10μg/ml), Pseudomonas aeruginosa(MIC=75μg/ml), Salmonella typhimurium(MIC=22.5μg/ml), Proteus mirabilis(MIC>200μg/ml), Serratia marcescens(MIC>200μg/ml);##Yeast: Candida albicans(MIC=100μg/ml).
Hemolytic Activity[Ref:11682065]1.1% hemolytic activity at 100μg/ml against human red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P0C008
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID11682065

Physicochemical Properties

Residues33
SequenceGLLDSIKGMAISAGKGALQNLLKVASCKLDKTC
Molecular Weight3348.01
Grand Average of Hydropathy0.361
Isoelectric Point9.243
Charge at pH 7.42.497
Secondary StructureHelix: 0.273, Turn: 0.242, Sheet: 0.333
Instability Index15.876
Aromaticity0

Similar Structure Search

Candidates based on structure

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