Basic Information

IDDRAMP01651
SequenceALWKDILKNVGKAAGKAVLNTVTDMVNQ
Length28
NameDermaseptin-B4 (Dermaseptin BIV; Frogs, amphibians, animals)
SourcePhyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-positive bacteria: Staphylococcus aureus ATCC 25293 (MIC=1.3 µM), S. aureus ATCC 25923 (MIC=3.0 µM);##Gram-negative bacteria: Pseudomonas aeruginosa CIP A22 (MIC=4.6 µM), Pseudomonas aeruginosa ATCC 27853 (MIC=11.6 µM), Escherichia coli ATCC 25922 (MIC=5.0 µM), E. coli 54127 (MIC=2.3 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity[Ref.9614066]No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot P81486
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID9614066

Physicochemical Properties

Residues28
SequenceALWKDILKNVGKAAGKAVLNTVTDMVNQ
Molecular Weight2998.499
Grand Average of Hydropathy0.075
Isoelectric Point9.529
Charge at pH 7.41.599
Secondary StructureHelix: 0.321, Turn: 0.179, Sheet: 0.286
Instability Index4.093
Aromaticity0.036

Similar Structure Search

Candidates based on structure

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