Basic Information

IDDRAMP01833
SequenceRAGLKFPVGRVHRLLR
Length16
NameBuforin-EC (Frogs, amphibians, animals)
SourceEuphlyctis cyanophlyctis (Skittering frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Swiss_Prot Entry C0HJB7]Gram-negative bacteria: Escherichia coli HP101BA (MIC=9.6 µM), Klebsiella pneumoniae PTCC1388 (MIC=10.6 µM);##Gram-positive bacteria: Micrococcus luteus PTCC1625 (MIC=6.0 µM), Staphylococcus aureus PTCC1431 (MIC=8.1 µM).
Hemolytic Activity[Ref.Int J Pept Res Ther(2012)18;107.]<3% hemolytic activity at 60 µg/ml against human red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot C0HJB7
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed IDPubMed ID is not available

Physicochemical Properties

Residues16
SequenceRAGLKFPVGRVHRLLR
Molecular Weight1875.274
Grand Average of Hydropathy-0.194
Isoelectric Point12
Charge at pH 7.44.591
Secondary StructureHelix: 0.375, Turn: 0.188, Sheet: 0.250
Instability Index34.875
Aromaticity0.062

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