Basic Information

IDDRAMP01881
SequenceGVLDTFKDVAIGVAKGAGTGVLKALLCKLDKSC
Length33
NameBrevinin-2LTc (Frogs, amphibians, animals)
SourceHylarana latouchii (Broad-folded frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=60 µM), Rhodococcus rhodochrous X15 (MIC=30 µM);##Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=15 µM).
Hemolytic Activity[Ref.22426384] LD50>480 μM against human erythrocytes
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys27 and Cys33)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22426384

Physicochemical Properties

Residues33
SequenceGVLDTFKDVAIGVAKGAGTGVLKALLCKLDKSC
Molecular Weight3291.921
Grand Average of Hydropathy0.639
Isoelectric Point8.788
Charge at pH 7.41.497
Secondary StructureHelix: 0.333, Turn: 0.182, Sheet: 0.273
Instability Index-3.803
Aromaticity0.03

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