Basic Information

IDDRAMP02010
SequenceGLLDSLKGFAATAGKGVLQSLLSTASCKLAKTC
Length33
NameBrevinin-2 (Frogs, amphibians, animals)
SourceRana brevipoda porsa (Japanese frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.1449472]Gram-positive bacterium: Staphylococcus aureus (MIC=8 µg/ml);##Gram-negative bacterium: Escherichia coli (MIC=4 µg/ml).
Hemolytic Activity[Ref.1449472] high hemolytic activity
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys27 and Cys33)
Linear/Cyclic/BranchedCyclic
Uniprot P32424
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID1449472

Physicochemical Properties

Residues33
SequenceGLLDSLKGFAATAGKGVLQSLLSTASCKLAKTC
Molecular Weight3253.83
Grand Average of Hydropathy0.548
Isoelectric Point9.308
Charge at pH 7.42.499
Secondary StructureHelix: 0.273, Turn: 0.242, Sheet: 0.364
Instability Index35.742
Aromaticity0.03

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