Basic Information

IDDRAMP01914
SequenceGLLDTFKNLALNAAKSAGVSVLNSLSCKLSKTC
Length33
NameBrevinin-2GRa (Frogs, amphibians, animals)
SourceRana grahami (Asian frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacterium: Escherichia coli (MIC=12.5 µM);##Gram-positive bacterium: Staphylococcus aureus (MIC=50 µM).##Yeast: Candida albicans (MIC>100 µM).
Hemolytic Activity[Ref.16621155] LC50=140 μM against human erythrocytes.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys27 and Cys33)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16621155, 17272268

Physicochemical Properties

Residues33
SequenceGLLDTFKNLALNAAKSAGVSVLNSLSCKLSKTC
Molecular Weight3367.933
Grand Average of Hydropathy0.43
Isoelectric Point9.308
Charge at pH 7.42.499
Secondary StructureHelix: 0.303, Turn: 0.303, Sheet: 0.333
Instability Index11.633
Aromaticity0.03

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.