Basic Information

IDDRAMP01965
SequenceFLPIIAGIAAKFLPKIFCTISKKC
Length24
NameBrevinin-1BLc (Frogs, amphibians, animals)
SourceLithobates blairi (leopard frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.19254736]Gram-negative bacterium: Escherichia coli (MIC=25 µM);##Gram-positive bacterium: Staphylococcus aureus (MIC=1.5 µM);##Yeast: Candida albicans (MIC=3 µM);##Cancer cells HepG2: (LC50=6 µM)..
Hemolytic Activity[Ref.19254736] LC50=9 μM against human red blood cells.##[Ref.14531844]Non-hemolytic activity against human erythrocytes
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot B6CPR0
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID19254736

Physicochemical Properties

Residues24
SequenceFLPIIAGIAAKFLPKIFCTISKKC
Molecular Weight2623.312
Grand Average of Hydropathy1.175
Isoelectric Point9.701
Charge at pH 7.43.498
Secondary StructureHelix: 0.417, Turn: 0.167, Sheet: 0.208
Instability Index32.142
Aromaticity0.125

Similar Structure Search

Candidates based on structure

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