Basic Information

IDDRAMP01920
SequenceFLPILAGLAAKIVPKLFCLATKKC
Length24
NameBrevinin-1CSa (Frogs, amphibians, animals)
SourceRana cascadae (Cascades frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.17451843]Gram-negative bacterium: Escherichia coli (MIC=32 µM);##Gram-positive bacterium: Staphylococcus aureus (MIC=2 µM).
Hemolytic Activity[Ref.17451843] LD50=5 µM against human erythrocytes
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys18 and Cys24)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID17451843

Physicochemical Properties

Residues24
SequenceFLPILAGLAAKIVPKLFCLATKKC
Molecular Weight2559.269
Grand Average of Hydropathy1.254
Isoelectric Point9.701
Charge at pH 7.43.498
Secondary StructureHelix: 0.417, Turn: 0.125, Sheet: 0.375
Instability Index31.071
Aromaticity0.083

Similar Structure Search

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