Basic Information

IDDRAMP02049
SequenceFLPAVLLVATHVLPTVFCAITRKC
Length24
NameBrevinin-1-OR10 (Frogs, amphibians, animals)
SourceOdorrana rotodora (Chinese odorous frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.4 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=27.2 µg/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.8 µg/ml).##Yeast: Candida albicans (MIC=6.8 µg/ml).
Hemolytic Activity[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 μg/mL.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys18 and Cys24)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22029824

Physicochemical Properties

Residues24
SequenceFLPAVLLVATHVLPTVFCAITRKC
Molecular Weight2613.234
Grand Average of Hydropathy1.483
Isoelectric Point8.957
Charge at pH 7.41.543
Secondary StructureHelix: 0.458, Turn: 0.083, Sheet: 0.292
Instability Index33.658
Aromaticity0.083

Similar Structure Search

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