Basic Information

IDDRAMP02040
SequenceFLPAVIRVAANVLPTAFCAISKKC
Length24
NameBrevinin-1-OA12 (Frogs, amphibians, animals)
SourceOdorrana andersonii (Chinese odorous frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.6 µg/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.6 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=13.2 µg/ml).##Yeast: Candida albicans (MIC=3.3 µg/ml).
Hemolytic Activity[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 μg/mL.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys18 and Cys24)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22029824

Physicochemical Properties

Residues24
SequenceFLPAVIRVAANVLPTAFCAISKKC
Molecular Weight2533.106
Grand Average of Hydropathy1.179
Isoelectric Point9.504
Charge at pH 7.42.503
Secondary StructureHelix: 0.375, Turn: 0.167, Sheet: 0.292
Instability Index33.658
Aromaticity0.083

Similar Structure Search

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