Basic Information

IDDRAMP01341
SequenceFLPLAVSLAANFLPKLFCKITKKC
Length24
NameAmolopin-1b (Frogs, amphibians, animals)
SourceAmolops loloensis (Rufous-spotted torrent frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Staphylococcus aureus (MIC=5.50 µg/ml), Bacillus dysenteriae (MIC=2.20 µg/ml);##Gram-negative bacterium: Escherichia coli (MIC=6.50 µg/ml).##Yeast: Candida albicans (MIC=7.50 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity[Ref.17000029]Display cytotoxicity against HepG2(IC50=58 mg/ml).
N-terminal ModificationFree
C-terminal ModificationCyclization(Cys18 and Cys24)
Linear/Cyclic/BranchedCyclic
Uniprot A0SN42
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID17000029

Physicochemical Properties

Residues24
SequenceFLPLAVSLAANFLPKLFCKITKKC
Molecular Weight2666.336
Grand Average of Hydropathy0.946
Isoelectric Point9.701
Charge at pH 7.43.498
Secondary StructureHelix: 0.417, Turn: 0.167, Sheet: 0.333
Instability Index12.296
Aromaticity0.125

Similar Structure Search

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