Basic Information

IDDRAMP02136
SequenceGLLGPLLKIAAKVGSNLL
Length18
NameAntimicrobial peptide 7 (XT-7; Frogs, amphibians, animals)
SourceXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacterium: Staphylococcus aureus (MIC=5 µM);##Gram-negative bacterium: Escherichia coli (MIC=5 µM);##yeast Candida albicans (MIC=40 µM).##Clinical isolates: Staphylococcus aureus 8325 (MIC=6 µM), Staphylococcus aureus (MRSA) (MIC=7 µM), Staphylococcus epidermidis 1420129 (MIC=3 µM), S. saprophyticus 1950556 (MIC=13 µM), Escherichia coli 25922 (MIC=6 µM), Streptococcus group C 1541035 (MIC=3 µM), Shigella sonnei 1840187 (MIC=35 µM), Pseudomonas aeruginosa 0380972 (MIC=60 µM), Enterobacter cloacae 1441323 (MIC=35 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P84381
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID11738090

Physicochemical Properties

Residues18
SequenceGLLGPLLKIAAKVGSNLL
Molecular Weight1777.199
Grand Average of Hydropathy1.122
Isoelectric Point10.003
Charge at pH 7.41.552
Secondary StructureHelix: 0.444, Turn: 0.333, Sheet: 0.444
Instability Index-9.422
Aromaticity0

Similar Structure Search

Candidates based on structure

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