Basic Information

IDDRAMP29131
SequenceKLLGPLLKIAAKVGSNLL
Length18
NameXT-7 [G1K]
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.18554256]Gram-negative bacteria:Escherichia coli ATCC 25726(MIC=25 µM);##Gram-positive bactria:Staphylococcus aureus ATCC 25923(MIC=12.5 µM);##Fungi:Candida albicans ATCC 900280(MIC=50 µM);##Cancer:human hepatoma‐derived cells HepG2 (LC50=230 µM).
Hemolytic Activity[Ref.18554256]Hemolysis against human erythrocytes (LC50=400 µM).
Cytotoxicity[Ref.18554256]No cytotoxicity information found.
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot P84381
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID18554256

Physicochemical Properties

Residues18
SequenceKLLGPLLKIAAKVGSNLL
Molecular Weight1848.32
Grand Average of Hydropathy0.928
Isoelectric Point10.302
Charge at pH 7.42.55
Secondary StructureHelix: 0.444, Turn: 0.278, Sheet: 0.444
Instability Index-14.139
Aromaticity0

Similar Structure Search

Candidates based on structure

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