Basic Information

IDDRAMP01416
SequenceGILSTVFKAGKGIVCGLSGLC
Length21
NameNigrocin-2ISc (Frogs, amphibians, animals)
SourceOdorrana ishikawae (Ishikawa's frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacterium: Escherichia coli (MIC=50 µM);##Gram-positive bacterium: Staphylococcus aureus (MIC=3 µM).##Yeast: Candida albicans (MIC=100 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys15 and Cys21)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID21867685

Physicochemical Properties

Residues21
SequenceGILSTVFKAGKGIVCGLSGLC
Molecular Weight2023.462
Grand Average of Hydropathy1.252
Isoelectric Point8.904
Charge at pH 7.41.503
Secondary StructureHelix: 0.381, Turn: 0.333, Sheet: 0.190
Instability Index-8.676
Aromaticity0.048

Similar Structure Search

Candidates based on structure

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