Basic Information

IDDRAMP02257
SequenceLMDTVKNVAKNLAGHMLDKLKCKITGC
Length27
NameRanatuerin-2P (Ranatuerin 2P; Frogs, amphibians, animals)
SourceRana pipiens (Northern leopard frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal,Antiviral
Pathogen[Ref.10651828] Gram-positive bacteria: Staphylococcus aureus (MIC=50 µM);##Gram-negative bacterium: Escherichia coli (MIC=13 µM);##Yeast: Candida albicans (MIC=67 µM).##[Ref.11601906]Virus:##Frog Virus 3: 90% inhibition at 500 µM;##Channel Catfish Virus: 99% inhibition at 50 µM.
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found in the reference(s) presented
N-terminal ModificationFree
C-terminal ModificationCyclization of a C-terminal Cys residue (forming a disulfide bond)
Linear/Cyclic/BranchedCyclic
Uniprot Q8QFQ4, P82847
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID11601906, 10651828

Physicochemical Properties

Residues27
SequenceLMDTVKNVAKNLAGHMLDKLKCKITGC
Molecular Weight2945.59
Grand Average of Hydropathy0.059
Isoelectric Point9.243
Charge at pH 7.42.533
Secondary StructureHelix: 0.259, Turn: 0.148, Sheet: 0.296
Instability Index-12.726
Aromaticity0

Similar Structure Search

Candidates based on structure

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