Basic Information
| ID | DRAMP21232 |
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| Sequence | GIMDTVKNAAKNLAGQLLDKLKCKITAC |
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| Length | 28 |
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| Name | Ranatuerin-2PLx (R2PLx; Frogs, Amphibians, Animals) |
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| Source | Lithobates palustris (Pickerel frog) (Rana palustris) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.30279210] Gram-positive bacteria : Staphylococcus aureus(NCTC 10788)(MIC=32 μM, MBC=128 μM), MRSA (ATCC 12493)(MIC=256 μM, MBC=512 μM), Enterococcus faecalis(NCTC 12697)(MIC=128 μM, MBC=512 μM);##Gram-negative bacteria : Escherichia coli(NCTC 10418)(MIC=32 μM, MBC=64 μM), Pseudomonas aeruginosa(ATCC 27853)(MIC>512 μM, MBC>512 μM);##Fungi : Candida albicans(NCTC 1467)(MIC=256 μM, MBC=512 μM) |
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| Hemolytic Activity | [Ref.30279210] 0% hemolysis at 4 μM , 1% hemolysis at 8 μM , 5% hemolysis at 16 μM , 10% hemolysis at 32 μM , 13% hemolysis at 64 μM , 20% hemolysis at 128 μM , 30% hemolysis at 256 μM , 44% hemolysis at 512 μM against human red blood cells |
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| Cytotoxicity | [Ref.30279210] No cytotoxicity information found |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
A0A3P8MS06 |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 30279210 |
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