Basic Information
| ID | DRAMP02292 |
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| Sequence | GIMSIVKDVAKNAAKEAAKGALSTLSCKLAKTC |
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| Length | 33 |
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| Name | Gaegurin-2 (Gaegurin 2; GGN2; Frogs, amphibians, animals) |
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| Source | Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
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| Pathogen | Gram-positive bacteria: Micrococcus luteus (MIC=2.5 µg/ml), Staphylococcus epidermidis (MIC=10 µg/ml), Bacillus subtilis (MIC=10 µg/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=25 µg/ml), Shigella dysentariae (MIC=25 µg/ml), Pseudomonas putida (MIC=50 µg/ml), Pseudomonas aeruginosa (MIC=50 µg/ml), Eshchericia coli (MIC=75 µg/ml).##Fungi: Saccharomyces cerevisiae (MIC=150 µg/ml), Candida albicans (MIC=150 µg/ml), Salmonella typhimurium (MIC=150 µg/ml), Proteus mirabilis (MIC>200 µg/ml), Serratia marcescens (MIC>200 µg/ml). |
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| Hemolytic Activity | [Ref.7999137] It has 0.19% hemolytic activity at 0.1 μg/ml, 0.16% hemolytic activity at 1 μg/ml, 0.31% hemolytic activity at 10 μg/ml, 0.82% hemolytic activity at 100 μg/ml against human red blood cells. |
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| Cytotoxicity | No cytotoxicity information found |
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| N-terminal Modification | Free |
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| C-terminal Modification | Cyclization (Cys27 and Cys33) |
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| Linear/Cyclic/Branched | Cyclic |
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| Uniprot |
P80396 |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 7999137 |
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