Basic Information

IDDRAMP02059
SequenceGVLATVKNLLIGTGDGAAQSVLKTLSCKLSNDC
Length33
NameBrevinin-2-OA6 (Frogs, amphibians, animals)
SourceOdorrana andersonii (Chinese odorous frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.2 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=44.8 µg/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=22.4 µg/ml).##Yeast: Candida albicans (MIC=11.2 µg/ml).
Hemolytic Activity[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 μg/mL.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys27 and Cys33)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22029824

Physicochemical Properties

Residues33
SequenceGVLATVKNLLIGTGDGAAQSVLKTLSCKLSNDC
Molecular Weight3290.806
Grand Average of Hydropathy0.455
Isoelectric Point8.033
Charge at pH 7.40.502
Secondary StructureHelix: 0.303, Turn: 0.273, Sheet: 0.273
Instability Index19.155
Aromaticity0

Similar Structure Search

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