Basic Information

IDDRAMP01510
SequenceGVFTLIKGATQLIGKTLGKELGKTGLELMACKITEQC
Length37
NameEsculentin-2-OR4 (Frogs, amphibians, animals)
SourceOdorrana rotodora (Chinese odorous frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacterium: Escherichia coli ATCC 25922 (MIC=3.6 µg/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=3.6 µg/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=3.6 µg/mL).##Yeast: Candida albicans ATCC 2002 (MIC=3.6 µg/mL).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity[Ref.22029824]No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys31 and Cys37)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22029824

Physicochemical Properties

Residues37
SequenceGVFTLIKGATQLIGKTLGKELGKTGLELMACKITEQC
Molecular Weight3894.665
Grand Average of Hydropathy0.295
Isoelectric Point8.788
Charge at pH 7.41.499
Secondary StructureHelix: 0.297, Turn: 0.162, Sheet: 0.324
Instability Index12.919
Aromaticity0.027

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.