Basic Information

IDDRAMP01505
SequenceGLFTLIKGAAKLIGKTTAKEAGKTGKLEMACKITNQC
Length37
NameEsculentin-2-OA2 (Frogs, amphibians, animals)
SourceOdorrana andersonii (Chinese odorous frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacterium: Escherichia coli ATCC 25922 (MIC=10.8 µg/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=21.6 µg/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=21.6 µg/mL).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity[Ref.22029824]No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys31 and Cys37)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22029824

Physicochemical Properties

Residues37
SequenceGLFTLIKGAAKLIGKTTAKEAGKTGKLEMACKITNQC
Molecular Weight3838.606
Grand Average of Hydropathy0.016
Isoelectric Point9.7
Charge at pH 7.44.493
Secondary StructureHelix: 0.216, Turn: 0.162, Sheet: 0.324
Instability Index-6.143
Aromaticity0.027

Similar Structure Search

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