Basic Information

IDDRAMP02350
SequenceGWGSFFKKAAHVGKHVGKAALTHYL
Length25
NamePleurocidin (NRC-4; fish, chordates, animals)
SourcePseudopleuronectes americanus (Winter flounder 2-2.1)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacteria: Escherichia coli (MIC=2.2-3.3 µM), Leucothrix mucor (MIC>35.0 µM), Serratia marcescens (MIC>35.0 µM), Pseudomonas aeruginosa (MIC>35.0 µM), Aeromonas salmonicida (MIC=17.7-35.0 µM), Cytophaga aquatilis (MIC=2.2-4.4 µM), Pasteurella haemolytica (MIC=4.4-8.8 µM), Salmonella typhimurium I (MIC=8.8-17.7 µM), Salmonella typhimurium II (MIC=8.8-17.7 µM);##Gram-positive bacteria: Bacillus subtilis (MIC=1.1-2.2 µM), Staphylococcus aureus (MIC=17.7-35.0 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P81941, P81619, Q9PRJ9, Q90ZY0, Q90VW6
PDB 1Z64 
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID9115266

Physicochemical Properties

Residues25
SequenceGWGSFFKKAAHVGKHVGKAALTHYL
Molecular Weight2711.128
Grand Average of Hydropathy-0.068
Isoelectric Point10.177
Charge at pH 7.43.655
Secondary StructureHelix: 0.320, Turn: 0.200, Sheet: 0.240
Instability Index4.972
Aromaticity0.16

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Candidates based on structure

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