Basic Information

IDDRAMP02360
SequenceGWKSVFRKAKKVGKTVGGLALDHYLG
Length26
NamePleurocidin-like peptide AP1 (NRC-11; fish, chordates, animals; Predicted)
SourceHippoglossoides platessoides (American plaice AP1)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=8 µg/ml), A. salmonicida 97-4 (MIC=8 µg/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=4 µg/ml), S. enterica serovar Typhimurium 14028s (MIC=32 µg/ml), Pseudomonas aeruginosa K799 (MIC=32 µg/ml), Pseudomonas aeruginosa Z61 (MIC=4 µg/ml), Escherichia coli CGSC 4908 (MIC=4 µg/ml), E. coli UB1005 (MIC=16µg/ml), E. coli DC2 (MIC=4 µg/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=64 µg/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 µg/ml).##Yeast: Candida albicans C627 (MIC=32 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q7SZH4
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID12878506

Physicochemical Properties

Residues26
SequenceGWKSVFRKAKKVGKTVGGLALDHYLG
Molecular Weight2816.305
Grand Average of Hydropathy-0.231
Isoelectric Point10.295
Charge at pH 7.44.579
Secondary StructureHelix: 0.346, Turn: 0.231, Sheet: 0.192
Instability Index22.946
Aromaticity0.115

Similar Structure Search

Candidates based on structure

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