Basic Information

IDDRAMP02922
SequenceKCWNLRGSCREKCIKNEKLYIFCTSGKLCCLKPK
Length34
NameCanine beta-defensin (dogs, mammals, animals)
SourceCanis lupus familiaris (Dog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacteria: Escherichia coli 25922 (MIC=20 µg/ml), Escherichia coli 700336 (MIC=50 µg/ml);##Gram-positive bacteria: Klebsiella pneumoniae 10031 (MIC=20 µg/ml), Listeria monocytogenes 19115 (MIC=10 µg/ml), Staphylococcus aureus 10832 (MIC=100 µg/ml), N. gonorrhoeae 10150 (MIC=50 µg/ml).##Fungi: Candida albicans 14053 (MIC=50 µg/ml), Candida albicans 11006 (MIC=5 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID15845463

Physicochemical Properties

Residues34
SequenceKCWNLRGSCREKCIKNEKLYIFCTSGKLCCLKPK
Molecular Weight3994.862
Grand Average of Hydropathy-0.447
Isoelectric Point9.419
Charge at pH 7.46.393
Secondary StructureHelix: 0.265, Turn: 0.206, Sheet: 0.176
Instability Index33.606
Aromaticity0.088

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