Basic Information

IDDRAMP03600
SequenceEFELDRICGYGTARCRKKCRSQEYRIGRCPNTYACCLRKWDESLLNRTKP
Length50
NameHuman beta-defensin 4 (hBD-4, BD-4; Beta-defensin 104; Human, mammals, animals)
SourceHomo sapiens (Human)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-positive bacterium: Staphylococcus carnosus TM300 (MIC=4.5 µg/ml);##Gram-negative bacteria: Escherichia coli BL21 (MIC>100 µg/ml), Pseudomonas aeruginosa (MIC=4.1 µg/ml).##Yeast: Saccharomyces cerevisiae ATCC9763 (MIC>100 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedCyclic
Uniprot Q8WTQ1, Q496I2, Q496I3, Q496I4
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID11481241

Physicochemical Properties

Residues50
SequenceEFELDRICGYGTARCRKKCRSQEYRIGRCPNTYACCLRKWDESLLNRTKP
Molecular Weight5988.868
Grand Average of Hydropathy-1.008
Isoelectric Point9.272
Charge at pH 7.45.507
Secondary StructureHelix: 0.220, Turn: 0.180, Sheet: 0.200
Instability Index42.034
Aromaticity0.1

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Candidates based on structure

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