Basic Information

IDDRAMP03104
SequenceATCDLLSGTGINHSACAAHCLLRGNRGGYCNGKAVCVCRN
Length40
NameSapecin (defensins; Insects, animals)
SourceSarcophaga peregrina (Flesh fly)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-positive bacteria: Staphylococcus aureus FDA209P (MIC=5.0 µg/ml), Staphylococcus smith (MIC=5.0 µg/ml), Micrococcus luteus FDA16 (MIC=1.2 µg/ml), Micrococcus luteus IF03333 (MIC=1.2 µg/ml), Micrococcus luteus PC11001 (MIC=10.0 µg/ml), Bacillus subtilis NRRI B-558 (MIC=39.0 µg/ml), Bacillus subtilis PC1219 (MIC=20.0 µg/ml), Mycobacterium smegmatis ATCC607 (MIC=78.0 µg/ml), Corynebacterium bouis 1810 (MIC=2.5 µg/ml), Corynebacterium michiganense (MIC=2.5 µg/ml).##Gram-negative bacteria: Xantbmonas oryzae (MIC=20.0 µg/ml), Pseudomonas lachrymans (MIC=78.0 µg/ml), Escherichia coli NIHJ (MIC>78.0 µg/ml), Shigella sonnei JS11746 (MIC>78.0 µg/ml), Proteus vulgaris O X19 (MIC>78.0 µg/ml)
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedCyclic
Uniprot P18313
PDB 1L4V
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID3182836, 3182836, 2358424

Physicochemical Properties

Residues40
SequenceATCDLLSGTGINHSACAAHCLLRGNRGGYCNGKAVCVCRN
Molecular Weight4080.661
Grand Average of Hydropathy0.102
Isoelectric Point8.693
Charge at pH 7.42.529
Secondary StructureHelix: 0.200, Turn: 0.300, Sheet: 0.225
Instability Index16.605
Aromaticity0.025

Similar Structure Search

Candidates based on structure

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