Basic Information

IDDRAMP03137
SequenceATCDLLSGFGVGDSACAAHCIARGNRGGYCNSKKVCVCRN
Length40
NameDefensin-A (AaeDefA; Insects, animals)
SourceAedes aegypti (Yellowfever mosquito)
ActivityAntimicrobial, Antibacterial, Anti-Gram+
PathogenGram-positive bacteria: Enterobacter cloacae beta12 (MIC=1.2-2.4 µM), Aerococcus viridans (MIC=0.6-1.2 µM), Micrococcus luteus (MIC=0.6-1.2 µM), Bacillus rnegaterium (MIC=0.6-1.2 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedCyclic
Uniprot P91793, O77250, P91794, P91795, P91796, Q17EE3, Q6ITZ2, Q963E9
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID7633471, 7568275

Physicochemical Properties

Residues40
SequenceATCDLLSGFGVGDSACAAHCIARGNRGGYCNSKKVCVCRN
Molecular Weight4078.642
Grand Average of Hydropathy0.067
Isoelectric Point8.679
Charge at pH 7.42.491
Secondary StructureHelix: 0.200, Turn: 0.300, Sheet: 0.175
Instability Index19.793
Aromaticity0.05

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