Basic Information

IDDRAMP03124
SequenceATCDLASIFNVNHALCAAHCIARRYRGGYCNSKAVCVCRN
Length40
NameDef-AcAA (hybrid defensins; Insects, animals)
SourceAnopheles gambiae (African malaria mosquito)
ActivityAntimicrobial, Antibacterial, Anti-Gram+
PathogenGram-positive bacteria: Staphylococcus aureus strain 21 (IC90=1.56 µg/mL), Staphylococcus aureus strain 4 (IC90=3.125 µg/mL).##T1=100 mg/kg, T2>100 mg/kg.##T1, dose causing the first signs of toxicity on mice. T2, lethal dose.
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q17027
PDB 2NZ3
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID18214975

Physicochemical Properties

Residues40
SequenceATCDLASIFNVNHALCAAHCIARRYRGGYCNSKAVCVCRN
Molecular Weight4346.014
Grand Average of Hydropathy0.202
Isoelectric Point8.942
Charge at pH 7.43.527
Secondary StructureHelix: 0.250, Turn: 0.200, Sheet: 0.225
Instability Index20.69
Aromaticity0.075

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