Basic Information

IDDRAMP03286
SequenceAPGNKAECEREKGYCGFLKCSFPFVVSGKCSRFFFCCKNIW
Length41
NameOstricacin-2 (Beta-defensin 1; Birds, animals)
SourceStruthio camelus (Ostrich)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacterium: Staphylococcus aureus 1056-MRSA (MIC=1.25 µg/ml);##Gram-negative bacterium: Escherichia coli O157:H7 (MIC=0.96 µg/ml);##Yeast: Candida albicans 3153A (MIC=6.2 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedCyclic
Uniprot P85114
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16459058

Physicochemical Properties

Residues41
SequenceAPGNKAECEREKGYCGFLKCSFPFVVSGKCSRFFFCCKNIW
Molecular Weight4688.479
Grand Average of Hydropathy-0.08
Isoelectric Point8.888
Charge at pH 7.43.449
Secondary StructureHelix: 0.293, Turn: 0.268, Sheet: 0.146
Instability Index45.402
Aromaticity0.195

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