Basic Information

IDDRAMP03471
SequenceGFGCPGNQLKCNNHCKSISCRAGYCDAATLWLRCTCTDCNGKK
Length43
NameRecombinant Crassostrea Gigas Defensin (Cg-Def; molluscs, animals)
SourceCrassostrea gigas (Pacific oyster)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Micrococcus lysodeikticus (MIC=0.005-0.01 µM), Staphylococcus aureus (MIC=1.25-2.5 µM), Microbacterium maritypicum (MIC=0.5-1 µM), Bacillus megaterium (MIC>20 µM);##Gram-negative bacteria: Escherichia coli 363 (MIC=35-20 µM), Vibrio alginolyticus (MIC>20 µM), Salmonella typhimurium (MIC>20 µM).##Fungi: Fusarium oxysporum (MIC=9-4.5 µM), Botrytis cinerea (MIC>20 µM), Penicillium crustosum (MIC>20 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q4GWV4
PDB 2B68
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16246846

Physicochemical Properties

Residues43
SequenceGFGCPGNQLKCNNHCKSISCRAGYCDAATLWLRCTCTDCNGKK
Molecular Weight4642.332
Grand Average of Hydropathy-0.412
Isoelectric Point8.731
Charge at pH 7.43.386
Secondary StructureHelix: 0.163, Turn: 0.279, Sheet: 0.140
Instability Index41.179
Aromaticity0.07

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