Basic Information

IDDRAMP02427
SequenceGGYYCPFFQDKCHRHCRSFGRKAGYCGGFLKKTCICV
Length37
NameIxodes ricinus defensin def1 (Ticks, Arthropods, animals)
SourceIxodes ricinus (European tick)
ActivityAntimicrobial, Antibacterial, Anti-Gram+
PathogenGram-positive bacteria: Bacillus subtilis (MIC=1.5 µM), Micrococcus luteus(MIC=0.75 µM), Staphylococcus aureus (MRSA) (MIC=50 µM).
Hemolytic Activity[Ref.21504572] It has 2.9% and 75% hemolysis at concentrations of 12.5 μM and 100 μM against human erythrocytes .
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID21504572

Physicochemical Properties

Residues37
SequenceGGYYCPFFQDKCHRHCRSFGRKAGYCGGFLKKTCICV
Molecular Weight4237.957
Grand Average of Hydropathy-0.308
Isoelectric Point9.272
Charge at pH 7.45.467
Secondary StructureHelix: 0.270, Turn: 0.216, Sheet: 0.054
Instability Index50.027
Aromaticity0.189

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