Basic Information

IDDRAMP03486
SequenceGKIPVKAIKQAGKVIGKGLRAINIAGTTHDVVSFFRPKKKKH
Length42
NameManduca Sexta Moricin (MS moricin; Insects, animals)
SourceManduca sexta (Tobacco hornworm)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-negative bacteria: Klebsiella pneumoniae (MIC=6.25 µg/ml), Salmonella typhimurium (MIC=6.25 µg/ml), S. typhimurium DT104 (MIC=6.25 µg/ml), Escherichia coli O157:H7 (MIC=6.25 µg/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25 923 (MIC=6.25 µg/ml), Methicillin-resistant S. aureus ATCC 43 300 (MIC=6.25 µg/ml), Methicillin-resistant S. aureus ATCC BAA-39 (MIC=12.5 µg/ml), Listeria monocytogenes (MIC=6.25 µg/ml).##NOTE: MIC is defined as the lowest peptide concentration that gives no visible growth after overnight incubation in 100% Muller-Hinton broth.
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q86MA1
PDB 2JR8
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID18265434, 12706633

Physicochemical Properties

Residues42
SequenceGKIPVKAIKQAGKVIGKGLRAINIAGTTHDVVSFFRPKKKKH
Molecular Weight4538.436
Grand Average of Hydropathy-0.298
Isoelectric Point11.363
Charge at pH 7.49.609
Secondary StructureHelix: 0.286, Turn: 0.214, Sheet: 0.119
Instability Index22.067
Aromaticity0.048

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Candidates based on structure

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