Basic Information

IDDRAMP20880
SequenceRWKFLKKIEKVGRKVRDGVIKAGPAVGVVGQATSIYK
Length37
NameDAN2
SourceMonarch butterfly (Danaus plexippus)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.29501691] Gram-positive bacteria: Bacillus subtilis (MIC=50μ±μ19 μg/mL);##Gram-negative bacteria: Escherichia coli (MIC=2.1μ±μ0.7 μg/mL), Pseudomonas aeruginosa (MIC=5μ±μ2.5 μg/mL), Klebsiella pneumoniae (MIC=4.3μ±μ1.4 μg/mL);##Fungi: Candida albicans (MIC=72.5μ±μ35.2 μg/mL)
Hemolytic Activity[Ref.29501691] 0% haemolysis at 10 μg/ml, 0% haemolysis at 25 μg/ml, 0% haemolysis at 50 μg/ml, 0% haemolysis at 100 μg/ml, 0% haemolysis at 200 μg/ml against sheep red blood cells
Cytotoxicity[Ref.29501691] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot A0A212F3T6
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29501691

Physicochemical Properties

Residues37
SequenceRWKFLKKIEKVGRKVRDGVIKAGPAVGVVGQATSIYK
Molecular Weight4083.869
Grand Average of Hydropathy-0.214
Isoelectric Point10.768
Charge at pH 7.47.539
Secondary StructureHelix: 0.351, Turn: 0.189, Sheet: 0.135
Instability Index23.935
Aromaticity0.081

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