Basic Information

IDDRAMP20879
SequenceKWKIFKKIEKVGRNVRDGIIKAGPAVQVVGQATSIAK
Length37
NameDAN1
SourceDanaus plexippus (monarch butterfly)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.29501691] Gram-positive bacteria: Bacillus subtilis (MIC=131.3μ±μ46.1 μg/mL);##Gram-negative bacteria: Escherichia coli (MIC=4.9μ±μ2.3 μg/mL), Pseudomonas aeruginosa (MIC=7μ±μ0.8 μg/mL), Klebsiella pneumoniae (MIC=16.2μ±μ1.9 μg/mL)
Hemolytic Activity[Ref.29501691] 0% haemolysis at 10 μg/ml, 0% haemolysis at 25 μg/ml, 0% haemolysis at 50 μg/ml, 0% haemolysis at 100 μg/ml, 0% haemolysis at 200 μg/ml against sheep red blood cells
Cytotoxicity[Ref.29501691] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot A0A212EJN7
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29501691

Physicochemical Properties

Residues37
SequenceKWKIFKKIEKVGRNVRDGIIKAGPAVQVVGQATSIAK
Molecular Weight4034.795
Grand Average of Hydropathy-0.159
Isoelectric Point10.729
Charge at pH 7.46.541
Secondary StructureHelix: 0.324, Turn: 0.189, Sheet: 0.135
Instability Index7.984
Aromaticity0.054

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