Basic Information
| ID | DRAMP03735 |
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| Sequence | GKVWDWIKSTAKKLWNSEPVKELKNTALNAAKNLVAEKIGATPS |
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| Length | 44 |
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| Name | Opistoporin-1 (OP1; Non-disulfide-bridged peptide 3.5; Opistoporin-3, OP3; Arthropods, animals) |
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| Source | Opistophthalmus carinatus (African yellow leg scorpion) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
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| Pathogen | [Ref.12354111]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.5 µM), Escherichia coli DH5a (MIC=6.3 µM), Serratia marcescens ATCC 133880 (MIC=50 µM), Pseudomonas aeruginosa ATCC 257853 (MIC=12.5 µM), Klebsiella pneumoniae ATCC 13833 (MIC=6.3 µM), Salmonella choleraesuis ATCC 13311 (MIC=25 µM), Haemophilus influenzae ATCC 19418 (MIC=1.6 µM);##Gram-positive bacteria: Bacillus subtilis ATCC 6051 (MIC=12.5 µM), Bacillus subtilis IP 5832 (MIC=12.5 µM), Listeria monocytogenes NCTC 11994 (MIC=12.5 µM), Micrococcus luteus ATCC 9341 (MIC>50 µM), Enterococcus faecalis ATCC 19433 (MIC=12.5 µM), Staphylococcus aureus ATCC 292136.3 (MIC>50 µM), Streptococcus pneumoniae ATCC 33400 (MIC=12.5 µM), Nocardia asteroides ATCC 3308 (MIC>50 µM);##Fungi: Neurospora crassa (IC50=0.8 µM), Botrytis cinerea (IC50=3.1 µM), Fusarium culmorum (IC50=0.8 µM), Saccharomyces cerevisiae (IC50=2 µM). |
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| Hemolytic Activity | [Ref.12354111]10% hemolytic activity at 10 µM, 30% hemolytic activity at 100 µM against human red blood cells |
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| Cytotoxicity | Not included yet |
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| N-terminal Modification | Not included yet |
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| C-terminal Modification | Not included yet |
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| Linear/Cyclic/Branched | Not included yet |
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| Uniprot |
P83313, Q5VJS8, Q5VJT0 |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 12354111, 12457879, 14575699 |
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